Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa.
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PppA is a Ser/Thr phosphatase that antagonises PpkA; both act on Fha1 with reciprocal effects on the H1-T6SS.
"PpkA activity is antagonized by PppA, a Ser-Thr phosphatase. These proteins exhibit reciprocal effects on the H-T6SS by acting on an FHA domain-containing protein, termed Fha1."
Crystal structure of PppA from Pseudomonas aeruginosa, a key regulatory component of type VI secretion systems.
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PppA has a PPM core with a dinuclear manganese catalytic centre.
"PppA harbors a catalytic pocket containing two manganese ions which correspond to the canonical dinuclear metal center of Ser/Thr protein phosphatases including the bacterial PPM phosphatases and human PP2C."
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods