eif-2alpha (Q9BKU3, Y37E3.10) notes

Deep research: the falcon and perplexity-lite run failed (falcon timeout; perplexity unavailable). No deep-research file.
Q9BKU3 is the only UniProt entry for this gene (TrEMBL). All 8 GOA rows are IBA/IEA.

Key findings

• eIF2 alpha subunit PMID:32292896.
• Ser49 is the stress phosphosite PMID:32292896.
• ER stress needs eIF2alpha phosphorylation PMID:38161330.
• GCN-2 phosphorylates eIF2alpha under mitochondrial stress PMID:22719267.
• Neuronal S49D enhances dauer entry PMID:28292919. Semaphorin signaling lowers phospho-eIF2alpha PMID:18413715.

Curation decisions

• All translation-initiation IBA/IEA rows are accepted; ribosome binding is kept as non-core.
• NEW: GO:0036499 PERK-mediated unfolded protein response (IMP, PMID:38161330). Comparator: human EIF2S1 (P05198) carries
  GO:0036499 by IDA in GOA (QuickGO, checked 2026-10-08). Phospho-eIF2alpha is the effector that inhibits eIF2B; it is not
  only a substrate. The ER UPR module models eIF2alpha as a PEK-1 target, not a participant; the module curator should
  note this possible tension.