UniProtKB P42225 record for mouse Stat1
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STAT1 associates with the 13 kDa Gasdermin-D cleavage product and promotes CIITA transcription in the small intestine.
"associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA"
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway.
Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.
Identification of a nuclear Stat1 protein tyrosine phosphatase.
Expression and activation of STAT proteins during mouse retina development.
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.
Erythrocyte and leukocyte dynamics in the retinal capillaries of diabetic mice.
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation.
Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1.
Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes.
JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway.
Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation.
The composition and signaling of the IL-35 receptor are unconventional.
An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion.
Construction of a novel oligonucleotide array-based transcription factor interaction assay platform and its uses for profiling STAT1 cofactors in mouse fibroblast cells.
Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma.
TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways.
Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.
IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.
Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine.
Jak2 phosphorylates Stat1/Stat3
p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5
p-Y-Stat1,3,5 dimer translocates from the cytosol to the nucleus
Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated
Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol
Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate
p-Y-Stat1,3,5 dimer binds Socs3 gene
p-Y-Stat1,3,5 dimer binds Socs1 gene
Stat4 binds the Tbx21 (T-bet) gene
Stat1 and Nfatc1 bind the Tbx21 (T-bet) gene
Falcon deep research summary for mouse Stat1
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STAT1 is an interferon-activated STAT-family DNA-binding transcription factor.
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Falcon synthesis supports JAK-dependent phosphorylation, dimerization, nuclear translocation, and regulatory DNA binding as the central STAT1 mechanism.
AIGR curator notes for Stat1