Human GRXCR2 in porcine CL4 cells showed “selective localization of GRXCR2wt to microvilli”. The disease variant had reduced abundance and targeting. PMID:24619944(https://pmc.ncbi.nlm.nih.gov/articles/PMC4123198/).
Partial taperin depletion rescued hearing in Grxcr2-deficient mice; complete depletion rescued bundle shape without hearing recovery. PMID:30380417(https://pmc.ncbi.nlm.nih.gov/articles/PMC6317715/).
The eleven incoming contexts are reviewed individually: five ACCEPT, five KEEP_AS_NON_CORE and one TOO_GENERAL. No NEW assertion is proposed. Literal evidence codes, qualifiers and donor sets are preserved in the companion evidence file.
The follow-up supersedes the earlier no-NEW statement: all eleven incoming actions remain unchanged, and one ISS process proposal is added. The review now has twelve assertions and one core. The companion evidence records the independent comparator, ontology and PAINT checks.
Hearing rescue was incomplete and frequency dependent. PMID:30380417(https://pmc.ncbi.nlm.nih.gov/articles/PMC6317715/).