Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs).
Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart.
Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
The structure of phospholamban pentamer reveals a channel-like architecture in membranes.
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.
Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function.
Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump.
Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy.
Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome.
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Phospholamban spontaneously reconstitutes into giant unilamellar vesicles where it generates a cation selective channel.
The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes.
PRKACA phosphorylates PLN
The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum.
Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A.
Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.
Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.
Micropeptide hetero-oligomerization adds complexity to the calcium pump regulatory network.
Testosterone regulates cardiac contractile activation by modulating SERCA but not NCX activity.
Identifying cellular mechanisms of zinc-induced relaxation in isolated cardiomyocytes.