MEGF10 notes

Deep research status (2026-10-03)

No provider deep-research file exists for this gene. deep_research_wrapper.py human MEGF10 falcon --fallback perplexity-lite failed: Falcon/Edison returned 402 Payment Required, and the perplexity provider is not available in this environment. A retry with openai failed with invalid_api_key. The synthesis below was made by hand from cached publications. Every claim carries an inline citation and quote.

Identity and architecture

• UniProtKB:Q96KG7, 1140 aa, single-pass type I membrane protein.
• Domain organization matches C. elegans CED-1: PMID:17498693.
• Classified as a class F scavenger receptor: PMID:27170117.
• Tyrosine phosphorylated: PMID:23954233.

Family assignment (see projects/PANTHER_FAMILY_ASSIGNMENT_DISCREPANCIES.md)

• The UniProt DR PANTHER cross-reference (from InterPro) is PTHR24052:SF13. fetch-gene therefore pulled PTHR24052 family data.
• PANTHER 19.0's own classification places MEGF10 in PTHR24035:SF136. The CED-1/Draper subfamily, PTHR24035:SF109, sits in the same family.
• Its IBAs come from PAINT nodes PTN002372116, PTN009076277 and PTN002778616. Their sources include ced-1 (WB:WBGene00000415), Draper (FB:FBgn0027594) and mouse Megf10 (MGI:2685177).

Core: engulfment receptor for apoptotic cells (CED-1 ortholog)

• Functional ortholog of CED-1: PMID:17205124.
• Gain of function: PMID:27170117.
• Loss of function (mouse): PMID:27170117.
• Ligand: C1q, which itself binds phosphatidylserine: PMID:27170117. Disease mutations impair this binding: PMID:27170117.
• Localization during engulfment: PMID:17205124. Also PMID:17498693.
• CED-1 pathway partners: GULP1 (the CED-6 ortholog) PMID:17205124 and ABCA1 (the CED-7 ortholog) PMID:17205124.
• Endocytic adaptor: PMID:17643423.

Astrocyte-mediated synapse elimination (mouse)

• PMID:24270812. Also PMID:24270812. MEGF10 acts as the engulfment receptor here, so it does part of the work of synapse pruning.

Amyloid-beta uptake (cell lines)

• PMID:20828568. This fits the scavenger receptor activity definition, which lists amyloid-beta fibrils among ligands. Evidence comes only from overexpression and knockdown in cell lines, so no process annotation is proposed.

Retinal mosaic spacing (mouse): homotypic repulsion, not adhesion

• PMID:22407321.
• PMID:22407321.
• PMID:22407321.
• Consequence: GO:0034109 homotypic cell-cell adhesion (IDA, this paper) does not fit what the paper shows. The paper reports cell-cell recognition that leads to repulsion.

Skeletal muscle (EMARDD myopathy)

• PMID:22101682.
• PMID:28498977. Also PMID:28498977.
• Muscle roles are real but distinct from the conserved engulfment-receptor function. The mechanism (Notch modulation, Y1030 signaling) is incompletely defined, so these annotations are treated as non-core.

Open questions

• Does MEGF10 bind phosphatidylserine directly, or only through C1q (and other bridging molecules)?
• Which ligand drives the homotypic MEGF10 interaction in retina, given that no homophilic binding was detected?
• Is the Notch1 interaction direct, and does it explain the satellite-cell phenotypes?