file:human/C18orf21/C18orf21-hypotheses/duf4674-foldseek-only/openscientist.md

OpenScientist hypothesis run: C18orf21 DUF4674 fold assignment

Foldseek assigns the DUF4674/C18orf21 AlphaFold model to the RPP21 RNase P/MRP-subunit superfamily, and recent literature identifies the protein as RMP24, a constitutive subunit of the human RNase MRP complex - a strong lead to resolve the previously unknown molecular function (pending primary- literature verification; the cited 2025-2026 PMIDs are not yet cached).

"RPP21 orthologues from three species appear as the closest non-self structural homologs"

PMID:15489334

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

PMID:18669648

A quantitative atlas of mitotic phosphorylation

file:human/C18orf21/C18orf21-deep-research.md

Deep research synthesis of C18orf21 literature and databases

file:human/C18orf21/C18orf21-deep-research-falcon.md

Falcon deep research synthesis of C18orf21 RNase MRP evidence

file:human/C18orf21/C18orf21-bioinformatics/RESULTS.md

Bioinformatics analysis of C18orf21 structural and functional features