Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation by the MGI curatorial staff, curated orthology
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm.
A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool.
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney.
Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line.
Role of the nude gene in epithelial terminal differentiation.
Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes.
Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection.
Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice.
A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.
Gab1 is an integrator of cell death versus cell survival signals in oxidative stress.
A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis.
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.
Spatial and temporal patterns of ERK signaling during mouse embryogenesis.
Essential role for ERK2 mitogen-activated protein kinase in placental development.
Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis.
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.
Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo.
Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.
Bioinformatics and cellular signaling.
The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.
MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha.
MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.
p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1.
Vanishin is a novel ubiquitinylated death-effector domain protein that blocks ERK activation.
Treatment of cells with the angiogenic inhibitor fumagillin results in increased stability of eukaryotic initiation factor 2-associated glycoprotein, p67, and reduced phosphorylation of extracellular signal-regulated kinases.
Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway.
ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1.
Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory.
Functional expression in mammalian cells of a full-length cDNA coding for the pp42/MAP kinase (p42mapk) protein.
Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.
ERK is a novel regulatory kinase for poly(A) polymerase.
Molecular cloning of Ebitein1: a novel extracellular signal-regulated kinase 2-binding protein in testis.
Identification of ERK2-binding domain of EBITEIN1, a novel ERK2-binding protein.
IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development.
Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.
Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.
The ERK signaling cascade--views from different subcellular compartments.
Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis.
Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways.
The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.
Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain.
Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling.
Specific functions for ERK/MAPK signaling during PNS development.
Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12).
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.
MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells.
α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.
Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum.
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Crucial requirement of ERK/MAPK signaling in respiratory tract development.
FXR1P is a GSK3β substrate regulating mood and emotion processing.
Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes.
Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor, mZnR/GPR39.
Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter.
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
CCR1 Activation Promotes Neuroinflammation Through CCR1/TPR1/ERK1/2 Signaling Pathway After Intracerebral Hemorrhage in Mice.
Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway.
Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration.
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo.
Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase.
Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.
The motheaten mutation rescues B cell signaling and development in CD45-deficient mice.
A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.
Mapk1,(Mapk3) phosphorylate Npas4
Falcon deep research summary for mouse Mapk1