Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
BTBD3 controls dendrite orientation toward active axons in mammalian neocortex.
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Mouse Btbd3 orients primary dendrites of barrel-cortex layer 4 neurons toward active axons and translocates to the nucleus with neuronal activity.
"In developing mouse somatosensory cortex, endogenous Btbd3 translocated to the cell nucleus in response to neuronal activity and oriented primary dendrites toward active axons in the barrel hollow."
Btbd3 expression regulates compulsive-like and exploratory behaviors in mice.
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Btbd3 knockout mice show compulsive-like behaviour, but dendritic morphology outside sensory cortex is largely unaltered.
"Surprisingly, Btbd3 knockout mice only showed modest increases in spine density in the anterior cingulate, while dendritic morphology was unaltered elsewhere."
E3 ubiquitin ligase BTBD3 inhibits tumorigenesis of colorectal cancer by regulating the TYRO3/Wnt/β-catenin signaling axis.
A reference map of the human binary protein interactome.
Cell-type homologies and the origins of the neocortex.
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Layer 4 input and layer 5 output cell types are conserved across amniotes but form nuclei in birds rather than layers.
"forming nuclei in birds, cortical areas in reptiles, and cortical layers in mammals"
Levels of homology and the problem of neocortex.
Avian brains and a new understanding of vertebrate brain evolution.
Evolutionary convergence of sensory circuits in the pallium of amniotes.
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Chick, gecko and mouse pallial sensory-circuit neurons arise at different times and places, which the authors interpret as convergence.
"suggesting the convergence of high-order sensory processing across amniote lineages"
Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits.
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Birds lack a layered neocortex; songbird pallial projection neurons resemble neocortical neurons but have distinct developmental origins.
"These data suggest that songbird vocal circuits and the mammalian neocortex have distinct developmental origins yet contain transcriptionally similar neurons."
Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons.
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Proposes the RAR method that flagged chicken cerebral cortex development annotations as potential misannotations.
"we applied the approach to 20 commonly studied species in two recent UniProt-GOA releases and identified 250 potential misannotations"
BTBD3 chicken curation notes (manual literature review and QuickGO/OLS queries)