Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.
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SNF-12 is essential for both the neuroendocrine TGF-beta and the p38 MAPK pathways that induce epidermal AMPs
"Here, we identify the sodium-neurotransmitter symporter SNF-12, a member of the solute carrier family (SLC6), as being essential for both these immune signaling pathways."
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SNF-12 is essential for AMP induction after fungal infection and binds STA-2 directly.
"We also identify the STAT transcription factor-like protein STA-2 as a direct physical interactor of SNF-12 and show that the two proteins function together to regulate AMP gene expression in the epidermis"
The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression.
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SNF-12 binds STA-2 through its C terminus and is found in endosome-like vesicles.
"SNF-12 is found in endosome-like vesicles in the epidermis, where it may act as a signaling platform during the innate immune response."
Mechanisms of innate immunity in C. elegans epidermis.
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The transport substrate of SNF-12 is unknown.
"SNF-12/SLC6 is predicted to be a transporter of a bioactive amine, but its endogenous substrate has yet to be identified."
Microtubule plus-end dynamics link wound repair to the innate immune response.
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SNF-12 is in an undefined apical membrane compartment that does not colocalize with endosome, lysosome or plasma-membrane markers, and it is recruited to wounds along microtubules.
"SNF-12 localizes to apical clusters that are recruited at the wound site in a MT-dependent way."
WormBase gene description for snf-12 (worm)