Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
CG8353 vs characterised PTHR11644:SF2 cytidine deaminases
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Q9VLR2 is the complete canonical CG8353 product and retains the Cys3/Glu active site of tetrameric CDAs.
"Both FlyBase/RefSeq CG8353 protein products (NP_609196.1 and NP_001260233.1) are 170 aa and identical to Q9VLR2"
CDA-uniprot.txt (human cytidine deaminase P32320)
Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome.
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Eye-specific RNAi of CG8353, chosen as the fly ortholog of mouse Cda, enhanced CGG-repeat rough-eye toxicity in a FXTAS model. Disease-model genetic modifier phenotype, not annotated.
"Knockdown of seven of the eight genes resulted in enhancement of the rough-eye phenotype: CG8353"