Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones.
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Landmark paper establishing the UPRmt in C. elegans
"We found that the mitochondrial matrix HSP70 and HSP60 chaperones, encoded by the Caenorhabditis elegans hsp-6 and hsp-60 genes, were selectively activated by perturbations that impair assembly of multi-subunit mitochondrial complexes"
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hsp-60 and hsp-6 are selectively induced by mitochondrial protein folding stress
"hsp-6 and hsp-60 induction was specific to perturbed mitochondrial protein handling"
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UPRmt is distinct from heat shock and ER stress responses
"neither heat-shock nor endoplasmic reticulum stress nor manipulations that impair mitochondrial steps in intermediary metabolism or ATP synthesis activated the mitochondrial chaperone genes"
Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response.
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UBL-5 is required for UPRmt signaling
"RNAi of ubl-5, a gene encoding a ubiquitin-like protein, suppresses activation of the UPR(mt) markers hsp-60::gfp and hsp-6::gfp"
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hsp-60::GFP is a canonical UPRmt reporter
"suppresses activation of the UPR(mt) markers hsp-60::gfp and hsp-6::gfp by the zc32 mutation and by other manipulations that promote mitochondrial protein misfolding"
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UPRmt perturbation affects mitochondrial morphology
"Mitochondrial morphology and assembly of multi-subunit mitochondrial complexes of biotinylated proteins are also perturbed in ubl-5(RNAi) worms"
Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans.
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HSP-6 knockdown reduces HSP-60 levels
"Knockdown of HSP-6 by RNA interference in young adult nematodes caused a reduction in the levels of ATP-2, HSP-60 and CLK-1"
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Demonstrates interdependence of mitochondrial chaperones
"Mitochondrial HSP-60 and ATP-2 were also reduced following the reduction of HSP-6 during aging"
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Provides IDA evidence for mitochondrial localization
"leading to abnormal mitochondrial morphology and lower ATP levels"
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.
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DVE-1 and UBL-5 form complex during UPRmt
"Unfolded protein stress in the mitochondria correlates with complex formation between a homeodomain-containing transcription factor DVE-1 and the small ubiquitin-like protein UBL-5"
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DVE-1 binds promoters of mitochondrial chaperone genes including hsp-60
"Activation of the UPR(mt) correlates temporally and spatially with nuclear redistribution of DVE-1 and with its enhanced binding to the promoters of mitochondrial chaperone genes"
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ClpP is required for UPRmt signaling
"These events and the downstream UPR(mt) are attenuated in animals with reduced activity of clpp-1, which encodes a mitochondrial matrix protease homologous to bacterial ClpP"