Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Identification of a family of human F-box proteins.

Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy.

FBXL4 deficiency increases mitochondrial removal by autophagy.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

The FBXL family of F-box proteins: variations on a theme.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders.

A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF(FBXL4).

AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex

NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex

CAND1 binds cytosolic CRL E3 ubiquitin ligases

COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes

COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes

MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex

Transfer of Ub from E2 to substrate and release of E2

Release of E3 from polyubiquitinated substrate

Polyubiquitination of substrate

Interaction of E3 with substrate and E2-Ub complex

Mutations in FBXL4 cause mitochondrial encephalopathy and a disorder of mitochondrial DNA maintenance.

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors.

FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels.

The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein.

PPTC7 acts as an essential co-factor of the SCF(FBXL4) ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy.