Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
A proteome-scale map of the human interactome network.
Pore-forming activity and structural autoinhibition of the gasdermin family.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Gasdermin D pore structure reveals preferential release of mature interleukin-1.
SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage.
Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion.
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.
Functional chimeric mRNAs encode proteins in mammalian immunity.
Exocytosis of tertiary granule lumen proteins
Exocytosis of specific granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
GSDMD forms ringâshaped oligomers
GSDMD (1-275) binds bacterial cardiolipin
GSDMD oligomerizes into arc-, slit-shaped structures
Disulfiram covalently modifies Cys191 in GSDMD
GSDMD expression mediated by IRF2, IRF1
GSDMD (1-275) binds cardiolipin
Dimethyl fumarate modifies Cys191 in GSDMD