Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Identification and characterization of a novel diterpene gene cluster in Aspergillus nidulans.
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PbcR overexpression activates a cluster containing AN1593.4 and causes production of ent-pimara-8(14),15-diene.
"Overexpression of pbcR upregulated the transcription of seven genes in the identified cluster and led to the production of a diterpene compound, which was characterized with GC/MS as ent-pimara-8(14),15-diene."
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AN1593.4 is the HMG-CoA reductase encoded in the PbcR-activated diterpene cluster.
"The highly upregulated genes were homologous to GGPP synthase; AN1592.4 (307,000-fold), HMG-CoA reductase; AN1593.4 (12,000-fold)"
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The proposed model places AN1593.4 in the mevalonate pathway as the source of isoprenoid precursors for ent-pimara-8(14),15-diene biosynthesis.
"Based on the data presented here, we suggest a model for ent-pimara-8(14),15-diene biosynthesis in Aspergillus nidulans. Specifically, HMG-CoA reductase (AN1593.4) functions in the mevalonate pathway, which produces isoprenoid precursors."
Engineering Aspergillus nidulans for heterologous ent-kaurene and gamma-terpinene production.
UniProt record for Emericella nidulans AN1593
PAINT IBD nodes for PTHR10572