Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Combined Automated Annotation using Multiple IEA Methods
Deep research summary for PGRPLB in Anopheles gambiae
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PGRP-LB is a catalytic amidase PGRP that degrades peptidoglycan
"AgPGRP-LB is an amidase-type PGRP predicted to catalyze N-acetylmuramoyl-L-alanine hydrolysis within bacterial PGN"
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PGRP-LB negatively regulates IMD/REL2 signaling
"By degrading DAP-type PGN that activates the IMD pathway, PGRP-LB dampens IMD/REL2 signaling"
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PGRP-LB maintains gut immune homeostasis
"PGRP-LB function is situated within gut/midgut immunity and microbiota homeostasis"
OpenScientist focused report on PGRP-LB immune receptor, defense and localization scope
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PGRP-LB is best interpreted as a catalytic peptidoglycan amidase, while the signal-initiating peptidoglycan receptor role belongs to PGRP-LC.
"The gene product's primary, best-supported function is a **secreted/extracellular DAP-type peptidoglycan amidase that negatively regulates the Imd immune response**"
UniProt entry for PGRP-LB (F5HMW5) in Anopheles gambiae
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Contains transmembrane domain
"Transmembrane helix {ECO:0000256|SAM:Phobius}"
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Member of amidase family
"Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family"
The Peptidoglycan Recognition Proteins PGRPLA and PGRPLB Regulate Anopheles Immunity to Bacteria and Affect Infection by Plasmodium.