"elegans ATF-7, a member of the conserved cyclic AMP-responsive element binding (CREB)/activating transcription factor (ATF) family of basic-region leucine zipper (bZIP) transcription factors and an ortholog of mammalian ATF2/ATF7, has a pivotal role in the regulation of PMK-1-mediated innate immunity"

"ATF-7 functions as a repressor of PMK-1-regulated genes that undergoes a switch to an activator upon phosphorylation by PMK-1"

"We used a mutated version of PMK-1 that does not have kinase activity to establish that ATF-7 and PMK-1 physically interact. Immunoprecipitation using the T7 antibody, followed by immunoblotting using anti-HA, revealed an HA-PMK-1(kinase-dead)-T7-ATF-7 interaction that was dependent on the activated form of PMK-1"

"loss of atf-7 activity also compromises pathogen resistance relative to WT"

"We observed that a rescuing translational fusion of ATF-7::GFP under the control of the endogenous promoter and 3′ UTR was strongly expressed in the nuclei of intestinal cells"

"common transcription factors control the innate immunity and 5-HT biosynthesis"

"TIR-1-induced tph-1 upregulation requires DAF-19 and ATF-7"

"common transcription factors control the innate immunity and 5-HT biosynthesis"

"elt-2 controls p38-dependent gene induction, cooperating with two p38-activated transcription factors, ATF-7 and SKN-1"

"elt-2 controls p38-dependent gene induction, cooperating with two p38-activated transcription factors, ATF-7 and SKN-1"

"The transcription factor ATF-7 was identified in both ethylmethanesulfonate mutagenesis and candidate gene screens"

"the regulatory factors and pathways that controlled cadmium-inducible transcription of the C. elegans metallothionein gene, mtl-1, were identified. The transcription factor ATF-7 was identified"

"Metallothioneins are conserved cysteine-rich proteins that function as efficient ROS scavengers and may affect longevity"

"We observed that 70% of genes significantly induced two-fold or greater by P. aeruginosa exposure were no longer fully induced upon loss of pmk-1, and that 53% of upregulated genes were no longer fully induced upon loss of atf-7"

"In all conditions analyzed, ATF-7 exhibited abundant association throughout the genome, with 8,962 total peaks identified as enriched by MACS2"

"MEME analysis of the most enriched loci identified significant enrichment for the motif GACgTCA, which corresponds to the Jun D bZIP motif expected for ATF-7 (Fig 2A, S3B Fig)"

"ATF-7 is preferentially located at the promoter regions of genes that are increased in expression by P. aeruginosa, and that this enrichment for ATF-7 is lessened by pmk-1 loss"

"ATF-7 exhibits binding affinity to regulators of autophagy (lgg-1), the Unfolded Protein Response (xbp-1), and the oxidative stress response (skn-1)"

"RNAi of 13 of 43 genes conferred enhanced sensitivity to killing by P. aeruginosa, without affecting survival on non-pathogenic E. coli"