MYH10 review notes

2026-09-27 (claude-code)

• Identity: human MYH10 (P35580), non-muscle myosin heavy chain IIB (not MYO10).
• Motor: PMID:15845534; PMID:24072716.
• Cytokinesis: PMID:15774463.
• Neuronal migration: mouse motor-domain mutant PMID:15034141 (cached, PubMed-verified); CGN leading process PMID:19607793; blebbistatin blocks MGE nucleokinesis PMID:15958735.
• Decisions: RNA stem-loop binding and mRNA 5'-UTR binding (PMID:20603131) REMOVE — full text says LARP6 is the only direct 5'SL binder and myosin is tethered via LARP6. Positive regulation of protein secretion MARK_AS_OVER_ANNOTATED (pharmacological, collagen-specific). Nucleus (sperm proteomics), exosome (HDA), spindle (IEA) marked over-annotated.
• NEW: GO:0001764 neuron migration (mouse Myh10 carries it by IMP; human lacks it because acts_upstream_of_or_within rodent rows are not propagated).
• Module check: GO:0000146 microfilament motor activity agrees. Paralog assignment for nucleokinesis rear contraction (IIA vs IIB) is not resolved by the pharmacological studies.
• Deep research (falcon) arrived later and was incorporated: consistent (tension-bearing NM2-B motor; neuronal soma/nuclear translocation).