Annotation inferences using phylogenetic trees

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

UniProtKB P32322 (P5CR1_HUMAN) record

Crystal structure of human pyrroline-5-carboxylate reductase.

Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae.

Mutations in PYCR1 cause cutis laxa with progeroid features.

Functional specialization in proline biosynthesis of melanoma.

DJ-1 cooperates with PYCR1 in cell protection against oxidative stress.

Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production.

Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH.

Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1.

A reference map of the human binary protein interactome.

PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro