Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:16169070

A human protein-protein interaction network: a resource for annotating the proteome.

PMID:17360703

V1 and V0 domains of the human H+-ATPase are linked by an interaction between the G and a subunits.

G1/a1, G3/a1, and G1/a4 interactions demonstrated experimentally; G and a subunit interaction is a novel link between V1 and V0 required for H+-ATPase assembly and regulation.

PMID:17897319

Integral and associated lysosomal membrane proteins.

Mass spectrometry identification of ATP6V1G1 in lysosome-enriched fractions supports lysosomal membrane localization.

PMID:19056867

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Identification in urinary exosome fraction; likely contamination rather than genuine exosomal loading.

PMID:21516116

Next-generation sequencing to generate interactome datasets.

PMID:22982048

Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.

V-ATPase disruption used as a tool to impair lysosomal activity; does not directly implicate ATP6V1G1 in macroautophagy regulation.

PMID:25416956

A proteome-scale map of the human interactome network.

PMID:28296633

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels.

ATP6V1G1 identified in genome-wide screen for HIF1alpha regulators; mechanism is indirect via iron depletion from impaired endosomal acidification leading to reduced PHD activity and HIF activation.

PMID:29993276

H(+)-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney.

H+-ATPase B1 subunit co-localizes with other H+-ATPase subunits at apical plasma membrane in kidney TAL and DCT.

PMID:30021884

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.

PMID:31515488

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

PMID:32296183

A reference map of the human binary protein interactome.

PMID:33065002

Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

Cryo-EM structures of complete human V-ATPase directly identify all V1 subunits; V1 complex contains three peripheral EG heterodimeric stalks.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Reactome:R-HSA-1222516

Intraphagosomal pH is lowered to 5 by V-ATPase

Reactome:R-HSA-5252133

ATP6AP1 binds V-ATPase

Reactome:R-HSA-74723

Endosome acidification

Reactome:R-HSA-917841

Acidification of Tf:TfR1 containing endosome

Reactome:R-HSA-9639286

RRAGC,D exchanges GTP for GDP

Reactome:R-HSA-9640167

RRAGA,B exchanges GDP for GTP

Reactome:R-HSA-9640168

v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine

Reactome:R-HSA-9640175

v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine

Reactome:R-HSA-9640195

RRAGA,B hydrolyzes GTP

Reactome:R-HSA-9645598

RRAGC,D hydrolyzes GTP

Reactome:R-HSA-9645608

v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1

Reactome:R-HSA-9646468

mTORC1 binds RHEB:GTP

Reactome:R-HSA-9858924

MITF-M-dependent ATP6V1G1gene expression