Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Towards a proteome-scale map of the human protein-protein interaction network.
Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.
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Human AKIRIN2 is a nuclear protein, and akirin proteins are conserved nuclear regulators of NF-kappaB-dependent transcription.
"Antibody staining of the human cells clearly showed the nuclear localization of HsAkirin1 and HsAkirin2"
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Mouse Akirin2 supports TLR/IL-1R-induced IL-6 expression downstream of NF-kappaB activation.
"MmAkirin2, but not MmAkirin1, was responsible for the production of IL-6 in response to TLR or IL-1R stimulation"
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Akirin specifies NF-kappaB selectivity of Drosophila innate immune response via chromatin remodeling.
Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses.
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Akirin2 is required for BRG1 (SWI/SNF) recruitment to the Myc and Ccnd2 promoters following mitogenic stimulation, supporting B-cell cycle progression, survival, and T-dependent and T-independent humoral immune responses.
Akirin2-Mediated Transcriptional Control by Recruiting SWI/SNF Complex in B Cells.
Architecture of the human interactome defines protein communities and disease networks.
Expression analysis of Akirin-2, NFκB-p65 and β-catenin proteins in imatinib resistance of chronic myeloid leukemia.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
AKIRIN2 controls the nuclear import of proteasomes in vertebrates.
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AKIRIN2 directly binds assembled proteasomes and mediates their nuclear import, which is the primary PN-relevant function for this review.
"directly bind to fully assembled 20S proteasomes"
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Loss of AKIRIN2 depletes nuclear proteasomes during mitotic nuclear reassembly and impairs nuclear protein degradation.
"nuclear protein degradation"
Multimodal cell maps as a foundation for structural and functional genomics.
UniProt text export for AKIRIN2 (Q53H80)
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UniProt summarizes AKIRIN2 as a molecular adapter for nuclear proteasome import and as a transcriptional co-regulator in immune/developmental contexts.
"directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end"
Proteostasis Network projected annotations report
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The PN projection proposes proteasome binding for AKIRIN2 from the proteasome-adaptor group; this review accepts it only because direct primary evidence supports proteasome binding.
"AKIRIN2 Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|Akirin"
AKIRIN2 curator notes for Proteostasis PN review