Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.

Tyrosine dephosphorylation, but not phosphorylation, of p130Cas is dependent on integrin alpha IIb beta 3-mediated aggregation in platelets: implication of p130Cas involvement in pathways unrelated to cytoskeletal reorganization.

Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in thrombospondin-treated smooth muscle cells.

Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin.

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.

Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.

Alternative splicing controls the mechanisms of FAK autophosphorylation.

Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.

Focal adhesion kinase regulation of N-WASP subcellular localization and function.

TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.

Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells.

Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway.

Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.

Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning.

Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.

Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.

Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.

Role of dystrophins and utrophins in platelet adhesion process.

Integrin-regulated FAK-Src signaling in normal and cancer cells.

Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5.

Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.

p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.

Structural basis for the interaction between focal adhesion kinase and CD4.

Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.

A novel Cas family member, HEPL, regulates FAK and cell spreading.

The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.

Mobility of TOAC spin-labelled peptides binding to the Src SH3 domain studied by paramagnetic NMR.

Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP.

EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.

Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2).

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility.

The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.

Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H.

Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells.

LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin.

Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.

SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration.

The role of focal adhesion kinase in early development.

Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium.

Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2.

Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains.

Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway.

Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects.

Proinvasion metastasis drivers in early-stage melanoma are oncogenes.

A directed protein interaction network for investigating intracellular signal transduction.

FAK promotes recruitment of talin to nascent adhesions to control cell motility.

Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes.

Activation of rapid oestrogen signalling in aggressive human breast cancers.

The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.

The protein interaction landscape of the human CMGC kinase group.

Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

The Chlamydia effector TarP mimics the mammalian leucine-aspartic acid motif of paxillin to subvert the focal adhesion kinase during invasion.

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury.

Phospho-tyrosine dependent protein-protein interaction network.

miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis.

Focal Adhesion Kinase Regulates Fibroblast Migration via Integrin beta-1 and Plays a Central Role in Fibrosis.

MicroRNA-92b represses invasion-metastasis cascade of esophageal squamous cell carcinoma.

MicroRNA-379-5p inhibits tumor invasion and metastasis by targeting FAK/AKT signaling in hepatocellular carcinoma.

Activation of focal adhesion kinase through an interaction with β4 integrin contributes to tumorigenicity of colon cancer.

Architecture of the human interactome defines protein communities and disease networks.

Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.

PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.

HENA, heterogeneous network-based data set for Alzheimer's disease.

De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

LncRNA FAISL Inhibits Calpain 2-Mediated Proteolysis of FAK to Promote Progression and Metastasis of Triple Negative Breast Cancer.

Multimodal cell maps as a foundation for structural and functional genomics.

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.

Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin.

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.

Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition.

Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.

Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix.

Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.

Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles.

Signaling by VEGF

Caspase-mediated cleavage of FADK 1

Fcgamma receptor (FCGR) dependent phagocytosis

Src phosphorylate WASP,N-WASP

Translocation of PTK2 to Focal complexes

Autophosphorylation of PTK2 at Y397

Recruitment of GRB2 to p-PTK2

Phosphorylation of pPTK2 by SRC

Interaction of SOS with GRB2 bound to FADK1

Phosphorylation of BCAR1 by SRC-PTK2 complex

Crk binding to p130cas

Recruitment of BCAR1 to PTK2 complex

DCC interacting NCK-1

Phosphorylation of DCC by Fyn

Recruitment of Grb2 to pFAK:NCAM1

SOS binds Grb2 bound to pFAK:NCAM1

NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras

p190RhoGEF exchanges GTP for GDP on RHOA, activating it

Recruitment of p190RhoGEF to p-FAK

Activation of Cdc42

Activation of Rac1

RhoGTPase GEF's recruited to DCC

Recruitment of Src and Fyn to DCC:FADK1

Recruitment and activation of N-WASP by Cdc42

PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2

SRC-1 phosphorylates p-Y397-PTK2

PTK2 autophosphorylates

HSP90AA1 binds p-6Y-VEGFR2

SRC-1 binds p-Y397-PTK2

PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118

DOCK180:ELMO binds CRK

Src kinases phosphorylate VAV

CRK binds BCAR1 and or PXN

Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732

SRC-1 phosphorylates PTK2-beta

PXN binds p-6Y,S732-PTK2

DOCK180:ELMO exchanges GTP for GDP, activating RAC1

p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407

RAS GEFs promote RAS nucleotide exchange

PTK2 autophosphorylates

PTK2 binds activated MET

SRC phosphorylates PTK2

MET phosphorylates PTK2

p-Y397-PTK2 binds SRC

PTK2 binds activated EGFR

PTK2 autophosphorylates downstream of EGFR

PTK2 is recruited to methylated ESR1

FCGR3A-mediated phagocytosis

Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells

p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)

Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow

Ancient origin of the integrin-mediated adhesion and signaling machinery.

Integrin-Mediated Adhesion in the Unicellular Holozoan Capsaspora owczarzaki.