GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000041

Gene Ontology annotation based on UniPathway vocabulary mapping

PMID:11069685

A novel NO-responding regulator controls the reduction of nitric oxide in Ralstonia eutropha.

Ralstonia has two NorR copies, norR1 and norR2, that control NO-responsive nitric oxide reductase transcription.

"The regulator gene maps adjacent to norAB, is divergently transcribed and present in two copies on the megaplasmid pHG1 (norR1) and the chromosome (norR2)."
NorR does not coordinate all denitrification steps.

"This reaction is not strictly co-ordinated on the regulatory level with the other nitrogen oxide-reducing steps of the denitrification chain that are independent of NorR."

PMID:15667304

Transcriptional regulation of nitric oxide reduction in Ralstonia eutropha H16.

NorR is an NO-responsive sigma-54-dependent activator that binds upstream activator sequences.

"norB and the adjacent norA form an operon that is controlled by the sigma(54)-dependent transcriptional activator NorR in response to NO."

PMID:16193057

A non-haem iron centre in the transcription factor NorR senses nitric oxide.

NorR-family proteins couple NO binding to ATPase-dependent transcription activation.

"Binding of NO stimulates the ATPase activity of NorR, enabling the activation of transcription by RNA polymerase."

file:CUPNH/norR2/norR2-uniprot.txt

UniProt record for norR2

UniProt describes NorR2 as required for NO-induced NO reductase expression and not required for nitrous oxide reductase expression.

file:CUPNH/norR2/norR2-deep-research-falcon.md

Falcon deep research for norR2

Deep research supports NorR2 as an NO-responsive sigma-54 enhancer-binding regulator of the chromosomal NOR2 system and explicitly marks detailed Fe-NO/GAF chemistry as family-level inference rather than direct biochemical evidence for Q9K4U8.

file:interpro/panther/PTHR32071/PTHR32071-deep-research-falcon.md

Falcon family deep research for PTHR32071 sigma-54-dependent transcriptional regulators

Family research found that the conserved sigma-54/AAA+ activation module is reused in many bacterial regulators, while N-terminal sensory domains define the regulated pathway and signal.