Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates.
EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid.
Gene CATCHR--gene cloning and tagging for Caenorhabditis elegans using yeast homologous recombination: a novel approach for the analysis of gene expression.
FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.
A strawberry notch homolog, let-765/nsh-1, positively regulates lin-3/egf expression to promote RAS-dependent vulval induction in C. elegans.
A RasGRP, C. elegans RGEF-1b, couples external stimuli to behavior by activating LET-60 (Ras) in sensory neurons.
Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.
let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein.
A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi.
Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory.
β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans.
Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation.
The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development.
The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling.
Identification of PLC210, a Caenorhabditis elegans phospholipase C, as a putative effector of Ras.
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans.
The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans.
-
Reduction-of-function let-60 mutations disrupt anterior cell fates in male spicule development.
"Reduction-of-function mutations in lin-3, let-23, sem-5, let-60 or lin-45 disrupt the fate of anterior cells."
The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans.
-
LET-60 Ras activity is needed in mature olfactory neurons for efficient odorant chemotaxis.
"Experiments in which let-60 ras was expressed using a heat-shock promoter and a cell-specific promoter show that a normal activity of LET-60 Ras is required in mature olfactory neurons."
WormBase gene description for let-60 (worm)