Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Structure of the T4 baseplate and its function in triggering sheath contraction.
-
Determines the atomic structure of the ~6-MDa T4 baseplate in pre- and post-attachment states, establishing the conserved inner baseplate core including gp53, gp6, and gp25 that triggers sheath contraction.
"Here we present the atomic structure of the approximately 6-megadalton bacteriophage T4 baseplate in its pre- and post-host attachment states and explain the events that lead to sheath contraction in atomic detail."
UniProtKB record for P16011 (53_BPT4)
-
gp53 is an inner baseplate protein located next to the tail tube that interacts with gp25 and the (gp6)2-gp7 heterotrimer during tail assembly.
"FUNCTION: Baseplate protein that is located next to the tail tube (inner baseplate). Involved in the tail assembly."
Deep research summary for Bacteriophage T4 gene 53 (gp53)
-
gp53 acts as a bundle clamp at the inter-wedge interface that promotes wedge circularization into the hexagonal baseplate and forms part of the sheath platform.
"gp53 is a structural baseplate wedge protein whose primary function is to bind at the interface between neighboring wedges, promoting wedge–wedge association (“circularization”) into the hexagonal baseplate."