Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.
Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.
Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.
Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.
Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4.
Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS.
Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.
Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation.
NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3.
Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8.
CCR3 is a target for age-related macular degeneration diagnosis and therapy.
-
Demonstrated CCL11/eotaxins promote endothelial cell proliferation, actin polymerization, and migration via CCR3.
-
Showed CCR3 targeting inhibits choroidal neovascularization.
-
Genetic ablation of Ccl11 reduced CNV in mice.
Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels.
Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α.
Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.
Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.
Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis.
-
Demonstrated CCL11 induces migration of RA FLS and THP-1 monocytes.
-
Showed CCL11 siRNA knockdown reduces FLS migration.
-
CCL11 levels elevated in RA serum and synovial fluid.
Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.
Receptor ACKR2 binds most inflammatory CC chemokines
Expression of STAT6-upregulated extracellular proteins