Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Towards a proteome-scale map of the human protein-protein interaction network.
A proteome-scale map of the human interactome network.
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase.
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Reversible UDP-sugar epimerization: recombinant human GALE interconverts UDP-galactose and UDP-glucose.
"catalyses the interconversion of
UDP-glucose and UDP-galactose."
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Homodimer formation: crosslinking supports human GALE dimer assembly, including the tested disease variants; assembly does not establish normal catalytic performance.
"Protein-protein crosslinking suggests that none of the
mutants are impaired in homodimer formation."
Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase.
Human UDP-galactose 4-epimerase. Accommodation of UDP-N-acetylglucosamine within the active site.
UDP-galactose 4'-epimerase activities toward UDP-Gal and UDP-GalNAc play different roles in the development of Drosophila melanogaster.
Defective GALE does not epimerise UDP-Gal to UDP-Glc
GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc
UniProtKB Q14376 (GALE_HUMAN)