Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry C5CVT2 (URED_VARPS): Urease accessory protein UreD
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Vapar_3971 (C5CVT2, ureD) is a Swiss-Prot reviewed 276-residue cytoplasmic urease accessory protein (HAMAP rule MF_01384, InterPro IPR002669, PANTHER PTHR33643:SF1) required for maturation of urease via functional incorporation of the nickel metallocenter as part of the UreD-UreF-UreG chaperone complex.
"CC -!- FUNCTION: Required for maturation of urease via the functional
CC incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC Rule:MF_01384}."
In vitro activation of urease apoprotein and role of UreD as a chaperone required for nickel metallocenter assembly.
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UreD binds the urease apoprotein and stabilizes an activation-competent conformation required for productive nickel incorporation into the active site.
"We propose that UreD is a chaperone protein which stabilizes a urease apoprotein conformation that is competent for nickel incorporation."
Klebsiella aerogenes UreF: identification of the UreG binding site and role in enhancing the fidelity of urease activation.
Complete genome sequence of the metabolically versatile plant growth-promoting endophyte Variovorax paradoxus S110.
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Genomic analysis of Variovorax paradoxus S110 highlights its diverse metabolic capabilities in soil and plant-associated environments.
"Variovorax paradoxus is a microorganism of special interest due to its diverse metabolic capabilities, including the biodegradation of both biogenic compounds and anthropogenic contaminants."