SNO1 (YMR095C, UniProt Q03144) – review notes

• PdxT/SNO class-I glutamine amidotransferase glutaminase subunit; UniProt function is by similarity [UniProt:Q03144 "Catalyzes the hydrolysis of glutamine to glutamate and"].
• Co-expressed with Snz1 forms a glutaminase-active complex; Sno1 alone barely active PMID:14764090 -> contributes_to glutaminase activity is correct.
• In vivo: PMID:30498136; PMID:12271461.
• Cytoplasmic in the GFP collection (PMID:14562095).
• Antiapoptosis claim (PMID:18355271): TSC22-like motif; Δsno1 is H2O2 hypersensitive PMID:18355271 – pleiotropic; marked over-annotated.
• GO issues: pyridoxine metabolic/biosynthetic process -> MODIFY (vitamin B6 biosynthesis / de novo PLP biosynthesis), consistent with SNO2 review; protein binding x3 -> REMOVE.
• Module: SNO1 is the PdxT exemplar (GO:0004359); consistent. YeastPathways PLPSAL-PWY has no SNO/SNZ genes.