Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.

Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase.

A protein tyrosine kinase in the interferon alpha/beta signaling pathway.

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.

Next-generation sequencing to generate interactome datasets.

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2.

A proteome-scale map of the human interactome network.

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.

A reference map of the human binary protein interactome.

SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2.

TODO: Fetch title

IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs.

Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.

Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.

Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha.

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.

Interleukin-23 binds interleukin-23 receptor

Interleukin-12 binds Interleukin-12 receptor

IL12RB1:TYK2 binds IL12RB2:JAK2

IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1

IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2

STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2

JAK1,TYK2 phosphorylate JAK1,TYK2

IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3

p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA

p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3

IL13RA1 binds TYK2

Interleukin-4 and Interleukin-13 signaling

SOCS5,(SOCS1) bind IL4RA

IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated

IL4:IL4R:JAK2 binds IL13RA1:TYK2

JAK1 binds IL4R in IL13-bound IL13R type II

IL13:IL13RA:TYK2 binds IL4R:JAK2

IL13 binds IL13RA:TYK2

STAT1,STAT3,STAT6 bind IL13:IL13R type II

STAT1,STAT3,STAT6 phosphorylation

p-Y-STATs dissociate

IL22:IL22RA1:JAK1 binds IL10RB:TYK2

Interleukin-12 dissociates from Interleukin-12 receptor

STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor

IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation

JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated

p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor

STAT4 binds to IL12RB2 in Interleukin-12 receptor complex

STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction

STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex

JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated

IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated

STAT4 binds p-Y-IL23R in IL23:IL23 receptor

p-Y693-STAT4 dissociates after IL12:IL12R interaction

p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor

IL12 bound to IL12R internalises

IL26:IL20RA:JAK1 binds IL10RB:TYK2

IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5

IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2

IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA

IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3

p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5

IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1

IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3

IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3

IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1

IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11

IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

IL10RB binds TYK2

p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1

p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3

IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3

IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5

Formation of p-STAT1 homodimer

Recruitment of STAT2 to p-IFNAR1

Release of p-STAT2:p-STAT1 dimer

Recruitment of IFNAR1

Phosphorylation of STAT1

Activation of JAK kinases

Phosphorylation of INFAR1 by TYK2

Phosphorylation of STAT2

Interferon alpha/beta signaling

p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS

IFNAR1:TYK2 binds TYK2 inhibitors

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7

CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane

NPM1-ALK-dependent TYK2 phosphorylation

Dephosphorylation of STAT1 by SHP2

Dephosphorylation of TYK2 by PTP1B

Dephosphorylation of JAK1 by SHP1

UniProtKB entry P29597 (TYK2_HUMAN), Non-receptor tyrosine-protein kinase TYK2