Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.
Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein.
DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions.
The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.
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Han11/DCAF7 provides the scaffold partner class used in the binding refinements. This class does not make DYRK1A a scaffold or establish purified direct contact for every deposited interaction.
"Han11 as a novel scaffold protein"
Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.
The protein interaction landscape of the human CMGC kinase group.
Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.
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Peptide profiling supports substrate recognition beyond a strictly proline-directed motif; the kinase refinement also retains demonstrated tyrosine autophosphorylation.
"DYRK1A is not a strictly proline-directed
kinase."
Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).
DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression.
A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.
Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.
Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
A High-Density Map for Navigating the Human Polycomb Complexome.
Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice.
Roles of tau protein in health and disease.
Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.
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A DYRK1A IDR fragment undergoes histidine-region-dependent phase separation in vitro. This construct result does not establish endogenous intact-product condensation; the live-cell cyclin-T1 experiments remain distinct.
"The longest stretch of IDR in DYRK1A promotes formation of phase-separated droplets in an HRD-dependent manner."
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.
DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Identification and functional characterization of transcriptional activators in human cells.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
Multimodal cell maps as a foundation for structural and functional genomics.
Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21.
Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region".
The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers.
Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.
Phosphorylation of LIN52 component of MuvB by DYRK1A
Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.
Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII.
Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A.
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DYRK1A and 9G8 affect Tau exon choice in a cell-dependent manner, supporting regulation of alternative splicing rather than a universal increase in splicing rate.
"these actions were variable depending on the cell
types."
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.
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DYRK1A interacts with and phosphorylates SRp55, providing a direct mechanism for its effect on alternative Tau exon choice.
"interacted with SRp55 and mainly phosphorylated its proline-rich
domain."
Form of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A nonphosphorylated at tyrosine 145 and 147 is enriched in the nuclei of astroglial cells, adult hippocampal progenitors, and some cholinergic axon terminals.
DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.
The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.
Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.
DDB1- and CUL4-associated factor 7
Phytanoyl-CoA hydroxylase-interacting protein
Sprouty-related, EVH1 domain-containing protein 2
Sprouty-related, EVH1 domain-containing protein 1
Retinoblastoma-associated protein
Retinoblastoma-like protein 1
Dynein light chain 1, cytoplasmic
Leucine zipper putative tumor suppressor 2
TNF receptor-associated factor 2
Keratinocyte proline-rich protein
Ubiquitin carboxyl-terminal hydrolase 54
Insulin-like growth factor 2 mRNA-binding protein 3
DNA-binding protein SATB1
Fragile X messenger ribonucleoprotein 1
E3 ubiquitin-protein ligase TRIP12
Insulin-like growth factor 2 mRNA-binding protein 1
MYND-type zinc finger-containing chromatin reader ZMYND8
Insulin-like growth factor 2 mRNA-binding protein 2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Subcellular - DYRK1A - The Human Protein Atlas