Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Combined Automated Annotation using Multiple IEA Methods

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.

RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.

E3 ligase RFWD3 participates in replication checkpoint control.

RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.

RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.

RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.

RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination.

Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia.

PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication.

The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.

RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks.

Multimodal cell maps as a foundation for structural and functional genomics.