Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Cell type specificity of a diffusible inducer is determined by a GATA family transcription factor.
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GtaC is a DIF-regulated GATA transcription factor that translocates to the nucleus in response to the morphogen DIF.
"gtaC expression is directly regulated by DIF, and GtaC rapidly translocates to the nucleus in response to DIF."
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GtaC is required for DIF-dependent pstB and basal-disc (stalk lineage) cell differentiation.
"GtaC is instead required to regulate DIF-dependent pstB and basal disc cell differentiation."
Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer.
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GtaC is a GATA family zinc finger transcription factor essential for early development; its gene disruption blocks aggregation.
"The insertion occurred in the second exon of the gtaC gene, which encodes a GATA family zinc finger transcription factor"
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GtaC undergoes oscillatory nucleocytoplasmic shuttling during early development, driven by periodic cAMP-receptor occupancy.
"nucleocytoplasmic shuttling of GtaC is driven by periodic occupancy of the surface receptor from self-organized cAMP oscillations."
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cAMP-receptor occupancy drives GtaC out of the nucleus, producing a transient burst of transcription at each cAMP cycle (developmental timer).
"receptor occupancy promotes nuclear exit of GtaC, which leads to a transient burst of transcription at each cAMP cycle"
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GtaC shuttling is required for proper developmental gene expression and progression.
"GtaC shuttling is required for proper control of developmental gene expression and development progression."
Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum.
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gtaC is a master transcriptional regulator whose expression, together with aggregation target genes, is dynamically regulated during development.
"The master transcriptional regulator gtaC, and several of its putative target genes involved in aggregation (such as the cell-cell adhesion gene csaA), looked markedly different at different time scales"
The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium.
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GtaC binds the promoter regions of ~2,091 genes genome-wide, with highly dynamic stage-specific DNA binding.
"We identified 2,091 genes whose promoter regions were bound by GtaC"
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GtaC binds a GATA-like DNA motif; this motif is enriched only in wild-type GtaC-bound regions.
"We found enrichment for a GATA-like motif only in regions bound by the WT GtaC"
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GtaC binding to GATA-like sequences directly upregulates target gene expression.
"GtaC binding to GATA-like sequences has a direct role in upregulating gene expression"
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GtaC decodes extracellular cAMP pulses to establish downstream signalling and ensure timely development; gtaC-null cells fail to aggregate.
"Cells lacking gtaC are defective in aggregation and in morphological and transcriptional progression."
An atypical MAPK regulates translocation of a GATA transcription factor in response to chemoattractant stimulation.
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Loss of GtaC enhances folate chemotaxis, indicating GtaC suppresses responses to folate.
"Loss of GtaC function resulted in enhanced chemotactic movement to folate, suggesting that GtaC suppresses responses to folate."
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The atypical MAPK Erk2 is required for GtaC translocation in response to both cAMP and folate chemoattractants.
"Erk2 was also found to be essential for the translocation of GtaC in response to external folate, a foraging signal that directs the chemotaxis of amoeba to bacteria."
Collective oscillatory signaling in Dictyostelium discoideum acts as a developmental timer initiated by weak coupling of a noisy pulsatile signal.