Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion.
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WarA binds c-di-GMP (DRaCALA) and shows SAM-dependent methyltransferase activity on LPS, which c-di-GMP stimulates; WarA interacts with SadC and WarB.
"We established that WarA binds to cyclic-di-GMP, which potentiates its methyltransferase activity."