Combined Automated Annotation using Multiple IEA Methods

file:PSEPK/hbdH/hbdH-uniprot.txt

UniProtKB entry for PSEPK hbdH

Q88IC6 is assigned EC 1.1.1.30 and the specific 3-hydroxybutyrate dehydrogenase family.

Cosubstrate-induced dynamics of D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida.

A P. putida D-3-hydroxybutyrate dehydrogenase has structural support for NAD+ and substrate binding.

"D-3-Hydroxybutyrate dehydrogenase from Pseudomonas putida belongs to the family of short-chain dehydrogenases/reductases."

The metabolism of (R)-3-hydroxybutyrate is regulated by the enhancer-binding protein PA2005 and the alternative sigma factor RpoN in Pseudomonas aeruginosa PAO1.

A Pseudomonas homolog converts R-3-hydroxybutyrate to acetoacetate during utilization.

"Essential to this utilization is the NAD+-dependent dehydrogenase BdhA that converts (R)-3-HB into acetoacetate"