Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy.
Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review).
Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization.
Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.
Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.
MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap.
Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation.
Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy.
Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation.
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling.
Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer.
Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.
A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).
Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization.
TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling.
Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling.
Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by downregulating RhoC and FZD4.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.
Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.
Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Quantitative fragmentomics allow affinity mapping of interactomes.
WNT:FZD complex promotes G-protein nucleotide exchange
G-protein subunits dissociate from WNT:FZD complex
USP8 deubiquitinates FZD to potentiate WNT signaling
ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex
ZNRF3 ubiquitinates FZD to promote its downregulation
DVL2 is phosphorylated by PKC
p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis
WNT5A:FZD4 is endocytosed
RNF43 frameshift mutants show enhanced WNT siganling
ARBB recruits GPCRs into clathrin-coated pits
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
UniProtKB Q9ULV1 (FZD4_HUMAN): Frizzled-4