Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Combined Automated Annotation using Multiple IEA Methods
Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae.
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TEP1 is a complement-like protein that binds to and kills Plasmodium parasites
"complement-like protein TEP1 from the mosquito Anopheles gambiae binds to and mediates killing of midgut stages of the rodent malaria parasite Plasmodium berghei"
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TEP1 knockdown abolishes melanotic refractoriness
"The dsRNA knockdown of TEP1 in adults completely abolishes melanotic refractoriness in a genetically selected refractory strain"
Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium.
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LRIM1 and APL1C stabilize circulating TEP1
"LRIM1 and APL1 not only stabilize circulating TEP1, they also stabilize each other prior to their interaction with TEP1"
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TEP1 circulates in hemolymph as part of a protein complex
"RNAi silencing of the LRR-encoding genes results in deposition of TEP1 on Anopheles tissues, thereby depleting TEP1 from circulation in the hemolymph and impeding its binding to Plasmodium"
The mosquito melanization response is implicated in defense against the entomopathogenic fungus Beauveria bassiana.
The CLIP-domain serine protease homolog SPCLIP1 regulates complement recruitment to microbial surfaces in the malaria mosquito Anopheles gambiae.
A serine protease homolog negatively regulates TEP1 consumption in systemic infections of the malaria vector Anopheles gambiae.
Complement-like proteins TEP1, TEP3 and TEP4 are positive regulators of periostial hemocyte aggregation in the mosquito Anopheles gambiae.