SGD gene description for VTC4 (yeast)
Vtc5 Is Localized to the Vacuole Membrane by the Conserved AP-3 Complex to Regulate Polyphosphate Synthesis in Budding Yeast.
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GFP-Vtc4 partly mislocalizes to the cytoplasm in apl5 (AP-3) mutants, an intermediate phenotype compared with Vtc5.
"GFP-Vtc4 showed an intermediate phenotype, with increased localization to the cytoplasm in apl5Δ, with some protein also remaining at the vacuole membrane"
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.
The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation.
Role of the Vtc proteins in V-ATPase stability and membrane trafficking.
The vacuolar transporter chaperone (VTC) complex is required for microautophagy.
Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.
Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins.
Trypanosoma brucei vacuolar transporter chaperone 4 (TbVtc4) is an acidocalcisome polyphosphate kinase required for in vivo infection.
Coupled synthesis and translocation restrains polyphosphate to acidocalcisome-like vacuoles and prevents its toxicity.
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.
Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.
Organelle size control - increasing vacuole content activates SNAREs to augment organelle volume through homotypic fusion.
The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex.
Cryo-EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit.
VTC4 curation notes (full-text excerpts of PMID:17079729)