Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
Drosophila Rheb GTPase is required for cell cycle progression and cell growth.
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase.
Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila.
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.
PDGF/VEGF signaling controls cell size in Drosophila.
Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism.
Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo.
Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis.
LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).
Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila.
Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1.
Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy.
Compensatory branching morphogenesis of stalk cells in the Drosophila trachea.
A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing.
Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye.
Inflammation-Modulated Metabolic Reprogramming Is Required for DUOX-Dependent Gut Immunity in Drosophila.
Hsp83/Hsp90 Physically Associates with Insulin Receptor to Promote Neural Stem Cell Reactivation.
STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation.
The neuronal ceroid lipofuscinosis protein Cln7 functions in the postsynaptic cell to regulate synapse development.
GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila.
DRheb is inhibited by the TSC1/2 complex
GEF binds to the inactive DRheb
GDP is exchanged for GTP on DRheb
GEF dissociates from DRheb-GTP
The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.
UniProtKB entry Q9VND8 (RHEB_DROME)
Manual literature summary for Drosophila Rheb