Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Regulation of the phospholipase C-gamma2 pathway in B cells.

Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor.

Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.

Activation of phospholipase Cgamma2 by tyrosine phosphorylation.

Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.

Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.

A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach.

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

Molecular profiling of isolated histological components of wilms tumor implicates a common role for the Wnt signaling pathway in kidney and tumor development.

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.

Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.

A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.

BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.

Fine specificity and molecular competition in SLAM family receptor signalling.

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

Phospho-tyrosine dependent protein-protein interaction network.

CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate

PLC gamma 2-mediated PIP2 hydrolysis

PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane

PLC-gamma1 hydrolyses PIP2

Phosphorylation and activation of PLCG

Recruitment of PLCgamma to membrane

Release of PLCG from FCGR

Phosphorylation of SLP-76 by p-SYK

Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT

Activation of RAC1 by VAV2/3

Recruitment of VAV and BTK to p-SLP-76

Phosphorylation of BTK by p-SYK

Release of p-PLCG1

Phosphorylation and activation of VAV2/VAV3 by SYK

Phosphorylation of PLC-gamma by p-BTK/p-SYK

Fc epsilon receptor (FCERI) signaling

Phosphorylation of TEC kinases by p-SYK

Activation of RAC1 by VAV

Phosphorylation and activation of VAV

Hydrolysis of PIP2 by PLCG

Phosphorylation of SLP-76 by p-SYK

Autophosphorylation of PAK

Autophosphorylation of BTK/ITK

Recruitment of PAK to the membrane by binding active RAC1

Recruitment of VAV to p-SLP-76

SLP-76 stimulates PLC gamma 2

p-Y753,Y759-PLCG2 hydrolyses PIP2

p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane

PLCG2 translocates from cytosol to plasma membrane

SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2

C-type lectin receptors (CLRs)

Platelet activation, signaling and aggregation

Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1

p-DAPP1 (p-BAM32) binds PLCG2

Recruitment of PLCgamma to membrane due to FCGR3A effect

Release of PLCG from FCGR3A

Phosphorylation and activation of PLCG due to FCGR3A effect

BTK binds BTK inhibitors

Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.