ARMCX6 is an X-linked armadillo repeat-containing protein whose direct mechanistic characterization is limited to its subcellular distribution and a self-associating transmembrane domain. GFP-tagged ARMCX6 localizes to the cytoplasm of HeLa cells PMID:22993554. Its transmembrane domain is capable of homotypic self-interaction, with an interface enriched in GxxxG motifs and composed of conserved, coevolved, polar residues PMID:33209210. Beyond these observations, no ARMCX6-specific function, substrate, or pathway role has been experimentally established in the available corpus; proposed roles in TRAK2/MIRO-dependent mitochondrial trafficking derive from subfamily-level data rather than direct study of ARMCX6 PMID:33267763.
| Year | Confidence | Finding | PMIDs | Journal |
|---|---|---|---|---|
| 2010 | Low | ARMCX6 tagged with green fluorescent protein localizes to the cytoplasm of HeLa cells, consistent with its membership in the ARMCX subfamily that harbors a mitochondrial targeting transmembrane domain. | PMID:22993554 | Experimental and therapeutic medicine |
| 2020 | Medium | The transmembrane domain (TMD) of ARMCX6 is capable of homotypic self-interaction; interfacial residues tend to be more conserved, coevolved, and polar than non-interfacial residues, and the interface is enriched in GxxxG motifs. | PMID:33209210 | Computational and structural biotechnology journal |
| 2021 | Low | ARMCX6, as a member of ARMCX subfamily 2, contains a mitochondrial targeting transmembrane domain and, together with other subfamily 2 members (ARMCX1, ARMCX2, ARMCX3) in complex with TRAK2 and MIRO, is involved in mitochondrial trafficking in axons and regulation of mitochondrial size and division, influencing the cell cycle. | PMID:33267763 | Current topics in medicinal chemistry |