Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes.
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AFAP1L1 interacts with cortactin SH3 domain via its proline-rich SH3-binding motif
"the SH3 binding motif of AFAP1L1 was more efficient at interacting with the SH3 domain of cortactin and not cSrc"
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AFAP1L1 localizes to actin filaments and invadosomes
"AFAP1L1 was shown by fluorescence microscopy to decorate actin filaments and move to punctate actin structures and colocalize with cortactin, consistent with localization to invadosomes"
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AFAP1L1 induces podosome formation when overexpressed
"Upon overexpression in A7r5 cells, AFAP1L1 had the ability to induce podosome formation and move to podosomes without stimulation"
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AFAP1L1 is expressed in unique tissue sites distinct from AFAP1
"localization of AFAP1L1 to unique sites in muscle and the dentate nucleus of the brain where AFAP1 was not detectable"
A proteome-scale map of the human interactome network.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway.
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AFAP1L1 is upregulated in gastric cancer and predicts poor prognosis
"AFAP1L1 was the only AFAP family members that was significantly upregulated in GC compared with normal gastric tissues"
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AFAP1L1 interacts with VAV2 to activate CDC42
"AFAP1L1 interacts with VAV guanine nucleotide exchange factor 2 (VAV2) to activate Rho family GTPases CDC42"
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AFAP1L1 promotes EMT and invasion via ITGA5/integrin signaling
"AFAP1L1 promotes GC cells proliferation, migration, invasion in vitro and tumor growth, metastasis in vivo by inducing epithelial-to-mesenchymal transition (EMT)"
Cyberian deep research review of AFAP1L1
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Comprehensive review synthesizing AFAP1L1 structure, function, and signaling mechanisms from multiple primary studies (PMID:26212012, PMID:37737201, PMID:29463794, PMID:27392663, PMID:23166755)
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AFAP1L1 SH3 binding motif exhibits approximately 9-fold higher affinity for cortactin SH3 domain compared to cSrc (from PMID:21333378)
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Phosphotyrosine-dependent signaling: pY136 binds Vav2 (Rho GTPase GEF) and pY566 binds Nck2 (actin-nucleating adaptor) (from PMID:26212012)
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AFAP1L1 regulates pathological angiogenesis via YAP-DLL4-NOTCH axis under hypoxia; HIF-1alpha activates AFAP1L1 transcription (from PMID:37737201)
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Sp3 transcription factor regulates basal AFAP1L1 expression; knockdown reduces invasion in osteosarcoma cells (from PMID:23166755)
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AFAP1L1 knockdown in NSCLC inhibits cell cycle, increases apoptosis via p38 MAPK activation (from PMID:29463794)
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AFAP1L1-mediated actin crosslinking provides physical barrier against Trypanosoma cruzi invasion (from PMID:27392663)