Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Cloning and characterization of a potential transcriptional activator of human gamma-globin genes.
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ANKRD49 has a potent N-terminal transactivation domain.
"Transactivation assays in the yeast hybrid system and transient transfection assays in COS cells showed that a potent trans-activating domain resides in the N-terminus of this protein."
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ANKRD49 may raise gamma-globin mRNA.
"Stable transfection assays provided evidence that the product of this gene may increase the level of gamma mRNA in HFE x MEL cell hybrids"
{gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice.
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FGIF reactivates gamma-globin in adult-type erythroid cells.
"was reactivated by an artificial zinc finger-gamma-globin transcription factor and the previously identified fetal globin transactivators fetal Krüppel-like factor (FKLF) and fetal globin-increasing factor (FGIF)."
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway.
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Ankrd repeats with a hydrophobic code bind RanGDP for nuclear import.
"AR-containing proteins (ARPs) with a hydrophobic residue at the 13th position of two consecutive ARs bind RanGDP efficiently, and consequently enter the nucleus."
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Architecture of the human interactome defines protein communities and disease networks.
Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis.
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ANKRD49 promotes NSCLC metastasis via JNK-c-Jun/ATF2 and MMP-2/9.
"ANKRD49 accelerated the invasion and metastasis of NSCLC cells via JNK-mediated transcription activation of c-Jun and ATF2 which regulated the expression of MMP-2/MMP-9."
ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38/ATF-2 signalling pathway.
ANKRD49 inhibits etoposide-induced intrinsic apoptosis of GC-1 cells by modulating NF-κB signaling.
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ANKRD49 reduces etoposide-induced intrinsic apoptosis via NF-kB.
"these results suggest that ANKRD49 plays an important role in reducing intrinsic apoptosis of GC-1 cells by modulating the NF-κB signaling pathway."
The Ankyrin Repeat Domain 49 (ANKRD49) Augments Autophagy of Serum-Starved GC-1 Cells through the NF-κB Pathway.
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ANKRD49 is nuclear in male germ cells.
"we found that ANKRD49 resides primarily in nucleus of spermatogonia, spermatocytes and round spermatids."
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ANKRD49 augments starvation-induced autophagy.
"ANKRD49 overexpression augments starvation-induced autophagy in male germ GC-1 cells whereas shRNA knockdown of ANKRD49 attenuates the autophagy."
ANKRD49 promotes the epithelial-mesenchymal transition of non-small cell lung cancer via the PKNOX1/TGF-β1/SMAD axis.
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ANKRD49 binds PKNOX1 and promotes TGF-B1 expression.
"Mechanistically, ANKRD49 physically interacts with PKNOX1, and PKNOX1 binds to the TGF-β1 promoter, elevating TGF-β1 expression and subsequently activating SMAD signaling."
UniProt entry Q8WVL7 (ANR49_HUMAN)
PTHR24198 PAINT annotations
Affinage mechanistic annotation for ANKRD49 (human)