Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
A novel subfamily of mitochondrial dicarboxylate carriers from Drosophila melanogaster: biochemical and computational studies.
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Reconstituted recombinant Dic4 showed no transport activity
"No transport activity was observed for DmDic4p."
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Dic4 is localized in mitochondria
"All expressed proteins are localized in mitochondria."
Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers.
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Dic4 catalysed neither homo- nor hetero-exchange after reconstitution
"Unexpectedly, DmDic4p was unable to catalyze either homo- or hetero-exchanges, after its reconstitution into liposomes"
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Loss of CP1/CP2 residues proposed to explain lack of dicarboxylate and phosphate transport
"As regards DmDic4p, its inability to transport dicarboxylates or phosphate could arise from a loss of some conserved residues located on CP1 and CP2."
OpenScientist assessment of Dic4 thiamine pyrophosphate transport
Dic4 placement within PTHR45618:SF13 (re-review phylogeny)
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PAINT NOT node removes dicarboxylate but not phosphate/sulfur-anion terms from Dic4
"The curator therefore deliberately withdrew dicarboxylate
transport from the Dic4 lineage but left the phosphate/sulfur-anion terms in place."
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SLC25A10 is a co-ortholog of the fly Dic expansion
"so SLC25A10 is a co-ortholog of the whole fly Dic expansion rather than a 1:1 ortholog of Dic4."