A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster.
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MESK2 was isolated as a misexpression modifier of RAS1/KSR signalling in the eye; the authors leave open whether such genes are pathway components or act in parallel pathways.
"These genes may represent new components of the RAS pathway or components of other signaling pathways that can modulate signaling by RAS."
Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila.
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Pan-glial RNAi knockdown of MESK2 with two independent transgenes reduced circadian locomotor rhythmicity.
"glial knockdown of MESK2 using either of two different RNAi transgenes also decreased rhythmicity"
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The biochemical role of MESK2 is unknown.
"Beyond a possible regulation of Ras/ERK signaling, there is little known about the biochemical role of MESK2 in Drosophila or mammals."
A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing.
A Superfamily-wide Activity Atlas of Serine Hydrolases in <i>Drosophila melanogaster</i>.
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Fluorophosphonate activity-based protein profiling mapped serine hydrolase activities across Drosophila stages and tissues; this is the source of the gene-level HDA serine hydrolase activity row on the canonical record Q7KVN0.
"leveraging discovery chemoproteomics, we identify and globally map the full complement of SH activities during various developmental stages and in different adult tissues of Drosophila"
Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor.
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Human NDRG2 retains the alpha/beta-hydrolase fold but lacks the catalytic triad.
"The most striking difference between NDRG2 and other members of ABH superfamily is the absence of the classical catalytic triad, Ser-His-Asp."
MESK2 re-review isoform identity and NDRG pseudo-active-site analysis
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Q8T0V2 shares an identical 338-residue block containing the whole Ndr domain with the canonical isoform Q7KVN0.
"Identical shared block: Q8T0V2 83-420 == Q7KVN0 1-338"
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MESK2 has Gly at the position of the catalytic serine nucleophile, as in human NDRG2.
"hNDRG2 146G -> Q8T0V2 (234, 'G')"
PAINT IBD assertions for PTHR11034
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PAINT places cytoplasm at the Eumetazoa node PTN000867215, the ancestor of fly MESK2 and vertebrate NDRG1-4.
"PTN000867215 GO:0005737 C IBD"
PANTHER PTHR11034 family review
Annotation inferences using phylogenetic trees
Falcon deep research report for MESK2