Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.

Characterization of interactions of Nck with Sos and dynamin.

Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.

Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin.

A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.

A novel proteomic screen for peptide-protein interactions.

Structural analysis of autoinhibition in the Ras activator Son of sevenless.

Binding of laminin alpha1-chain LG4-5 domain to alpha-dystroglycan causes tyrosine phosphorylation of syntrophin to initiate Rac1 signaling.

Stem cell factor and its receptor c-Kit as targets for inflammatory diseases.

Sos-mediated activation of rac1 by p66shc.

Catalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by phenylalanine 577.

Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes.

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.

Membrane-dependent signal integration by the Ras activator Son of sevenless.

Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1.

SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner.

Charting the molecular network of the drug target Bcr-Abl.

Isoform-selective interaction of the adaptor protein Tks5/FISH with Sos1 and dynamins.

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless.

SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration.

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

Toward an understanding of the protein interaction network of the human liver.

Wnt4 inhibits cell motility induced by oncogenic Ras.

Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.

Phase separation of signaling molecules promotes T cell receptor signal transduction.

Architecture of the human interactome defines protein communities and disease networks.

The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein.

Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

A reference map of the human binary protein interactome.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.

Studying early structural changes in SOS1 mediated KRAS activation mechanism.

Allosteric nanobodies to study the interactions between SOS1 and RAS.

Multimodal cell maps as a foundation for structural and functional genomics.

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.

Differential interactions of human Sos1 and Sos2 with Grb2.

The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.

T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras.

NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos.

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation.

Subsets of epidermal growth factor receptors during activation and endocytosis.

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Regulation of Sos activity by intramolecular interactions.

Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells.

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2.

The structural basis of the activation of Ras by Sos.

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.

GRB2-1 binds SOS1

MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1

MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2

BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate

Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)

Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex

Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4

GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers

RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers

Activation of RAS by p-KIT bound SOS1

Signaling by EGFR

GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)

GRB2:SOS1 complex binds to EGF:EGFR complex

SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)

GRB2:SOS1 complex binds to the active receptor

SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)

Cell surface interactions at the vascular wall

p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor

Recruitment of CBL to KIT

GRB2:SOS interacts with p-KIT

Interaction of SOS-1 to Tie2 bound Grb2

Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)

SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)

GRB2:SOS1 binds to HBEGF:p-Y-EGFR

Recruitment of GADS:SLP-76 to p-5Y-LAT

Phosphorylation of SLP-76 by p-SYK

Recruitment of GRB2:SOS to p-5Y-LAT

Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT

Activation of RAC1 by VAV2/3

SOS mediated nucleotide exchange of RAS (SHC)

Recruitment of VAV and BTK to p-SLP-76

Phosphorylation of BTK by p-SYK

Release of p-PLCG1

Phosphorylation and activation of VAV2/VAV3 by SYK

Phosphorylation of PLC-gamma by p-BTK/p-SYK

Fc epsilon receptor (FCERI) signaling

Phosphorylation of TEC kinases by p-SYK

Recruitment of GRB2:SOS to p-10Y-NTAL

Activation of RAC1 by VAV

Phosphorylation and activation of VAV

PI3K associates with phosphorylated GAB2

Interaction of GRB2:SOS complex with p-SHC1

Hydrolysis of PIP2 by PLCG

Phosphorylation of SLP-76 by p-SYK

Autophosphorylation of PAK

Autophosphorylation of BTK/ITK

Phosphorylation of PIP2 to PIP3 by PI3K

Recruitment of PAK to the membrane by binding active RAC1

Recruitment of VAV to p-SLP-76

Interaction of SOS with GRB2 bound to FADK1

SOS binds Grb2 bound to pFAK:NCAM1

NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras

GEFs activate RhoA,B,C

Axon guidance

Phosphorylated SHC recruits GRB2:SOS1

Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII

Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)

Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR2:p-SHC1 binds GRB2:SOS1

Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR3:pFRS binds GRB2:SOS1

Activated FGFR4:p-SHC1 binds GRB2:SOS1

Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR1:p-FRS binds GRB2:SOS1

Activated FGFR1:p-SHC1 binds GRB2:SOS1

Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR2:pFRS binds GRB2:SOS1

Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR3:p-SHC1 binds GRB2:SOS1

Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR4:p-FRS binds GRB2:SOS1

Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1

Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1

Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1

Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1

RAS GEFs promote RAS nucleotide exchange

GRB2-1:SOS1 binds p-Y-SHC

GRB2-1:SOS1 binds p-3Y-SHC1

GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates

GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates

GRB2-1:SOS1 binds p-IRS1,p-IRS2

GRB2-1:SOS1 binds p-Y427-SHC1

Activated MET recruits GRB2-1:SOS1

RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1

Activated MET binds RANBP9 and SOS1

RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET

RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET

SHC1-2 bound to MET recruits GRB2:SOS1

2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1

2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1

NTRK2-phosphorylated FRS2 binds GRB2

Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1

FLT3 Signaling

Active FLT3:GRB2 binds SOS1

SOS1-mediated nucleotide exchange of RAS downstream of FLT3

Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1

Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants

Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR

RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2

GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR

KIT mutants bind GRB2-SOS

p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS

GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers

SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers

GRB2:SOS1 complex binds to mutant PDGFR receptor

SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors

BTK binds BTK inhibitors

FLT3 mutant dimers:GRB2 bind SOS1

FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS

FLT3 fusions:GRB2 bind SOS1

SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants

p-6Y-SYK phosphorylates BLNK (SLP65)

Active LTK recruits GRB2:SOS1

Falcon deep-research report for human SOS1 (Q07889)