Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.

A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit.

Towards a proteome-scale map of the human protein-protein interaction network.

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling.

NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.

The complex structure of calmodulin bound to a calcineurin peptide.

CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells.

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.

Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation.

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.

Domain swapping and different oligomeric States for the complex between calmodulin and the calmodulin-binding domain of calcineurin a.

WITHDRAWN: USP14 stabilizes calcineurin and regulates NFAT/AP-1 dependent IL-4 transcription as a novel calcineurin-binding protein.

Calcineurin promotes proliferation, migration, and invasion of small cell lung cancer.

The effect of down regulation of calcineurin Aα by lentiviral vector-mediated RNAi on the biological behavior of small-cell lung cancer and its bone metastasis.

A directed protein interaction network for investigating intracellular signal transduction.

Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.

Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy.

The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.

The distal helix in the regulatory domain of calcineurin is important for domain stability and enzyme function.

Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein γ-8 with calcineurin.

A proteome-scale map of the human interactome network.

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization.

Calcineurin in a Crowded World.

Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.

The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton.

Overexpression of C16orf74 is involved in aggressive pancreatic cancers.

Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.

Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.

Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity.

Calcineurin binds NFATC1,2,3

Calcineurin binds and dephosphorylates NFAT

Translocation of CaN:CaM:NFAT to nucleus

Activation of Calcineurin

Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling

Translocation of NFATC1:CaN:CaM to nucleus

Deep research report on PPP3CA