Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation by the MGI curatorial staff, curated orthology
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts.
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.
Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis.
Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells.
Role of Gas6 in erythropoiesis and anemia in mice.
Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration.
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.
Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation.
UniProtKB Q61592 mouse GAS6 record
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Mouse GAS6 is a secreted ligand for TAM receptor tyrosine kinases AXL, TYRO3, and MER/MERTK.
"UniProt describes mouse GAS6 as a ligand for AXL, TYRO3 and MER receptor tyrosine kinases, with roles in cell growth, survival, adhesion, migration, platelet activation, and thrombotic responses."
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GAS6 has vitamin K-dependent gamma-carboxyglutamate residues essential for calcium binding and is annotated as secreted.
"UniProt annotates the mature mouse GAS6 protein as secreted and notes vitamin K-dependent gamma-carboxyglutamate residues required for calcium binding."
Falcon deep research report for mouse Gas6
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Falcon synthesizes GAS6 as a secreted TAM ligand that bridges phosphatidylserine-bearing membranes to TAM receptors and triggers receptor kinase signaling.
"Falcon summarizes mouse GAS6 as a secreted vitamin K-dependent ligand that bridges phosphatidylserine-bearing membranes to TAM receptors and triggers receptor dimerization and kinase activation."
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Falcon identifies efferocytosis, inflammatory regulation, and PI3K-AKT/ERK signaling as major GAS6/TAM functional outputs.
"Falcon highlights efferocytosis as a central GAS6/TAM function, with GAS6 bridging apoptotic-cell phosphatidylserine to TAM receptors on phagocytes."