Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

PMID:15314609

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics.

Ymer (CCDC50) is an EGF-induced tyrosine-phosphorylated protein involved in EGFR signaling.

PMID:17503326

A mutation in CCDC50, a gene encoding an effector of epidermal growth factor-mediated cell signaling, causes progressive hearing loss.

A CCDC50 mutation causes DFNA44 autosomal dominant progressive hearing loss; Ymer is a soluble cytoplasmic protein expressed in cochlear pillar cells, stria vascularis and vestibular sensory epithelia, and colocalizes with microtubules of the mitotic apparatus.

PMID:18029035

Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain.

Ymer interacts with A20 and binds K63-linked polyubiquitin on RIPK1; overexpression down-regulates NF-kB signaling and knockdown up-regulates it, establishing Ymer as a negative regulator of NF-kB signaling and a K63-polyubiquitin-binding protein.

PMID:23418353

The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.

RNF126 (a CCDC50/Ymer interactor) functions in ubiquitin-dependent endosomal sorting and degradation of EGFR downstream of c-Cbl.

PMID:32296183

A reference map of the human binary protein interactome.