Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.
-
DNER is a somatodendritic plasma-membrane and endosomal protein that binds AP-1.
"Direct in vivo binding of DNER to the coat-associated protein complex AP-1 strongly suggests that DNER undergoes AP-1-dependent sorting to the somatodendritic compartments from the trans-Golgi network and subsequent passage through the endosomal system."
A reference map of the human binary protein interactome.
DNER acts as a neuron-specific Notch ligand during Bergmann glial development.
-
Dner promotes Bergmann-glial radial-fiber differentiation in mouse cerebellum.
"Additionally, deficiency of DNER retards the formation of radial fibers and results in abnormal arrangement of Bergmann glia."
Impaired cerebellar functions in mutant mice lacking DNER.
-
Dner is required for normal cerebellar maturation and function in mouse.
"The cerebellum from the knockout mice showed significant retardation in morphogenesis and persistent abnormality in fissure organization."
Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis.
-
Pleiotrophin-PTPRZ signaling regulates DNER phosphorylation, trafficking, and neuritogenesis.
"These observations suggest that pleiotrophin-PTPzeta signaling controls subcellular localization of DNER and thereby regulates neuritogenesis."
Polarized targeting of DNER into dendritic plasma membrane in hippocampal neurons depends on endocytosis.
-
AP-2 binding and endocytosis regulate polarized DNER surface distribution.
"The DNER cytoplasmic domain binds to a clathrin adaptor protein complex-2 via a proximal tyrosine motif and a 40 amino acid stretch in the mid-domain, but not by the C-terminal tail."
Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
DNER manual evidence review notes